(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
Bay-K-8644 ((R)-(+)-)
CAS: 98791-67-4
Molecular Formula: C16H15F3N2O4
(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER - Names and Identifiers
(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER - Physico-chemical Properties
| Molecular Formula | C16H15F3N2O4 |
| Molar Mass | 356.3 |
| Solubility | 10 mM in DMSO |
| Appearance | solid |
| Color | yellow |
| Storage Condition | 2-8°C |
| In vitro study | (R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca 2+ channel agonist. Each optical isomer possesses opposite effects on I Ba , (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba 2+ currents (I Ba ) (IC 50 =975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, I Ba is suppressed to 71±10% of control. In the presence of (R)-(+)-Bay-K-8644I Ba . (R)-(+)-Bay-K-8644 is a calcium channel inhibitor. |
(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.807 ml | 14.033 ml | 28.067 ml |
| 5 mM | 0.561 ml | 2.807 ml | 5.613 ml |
| 10 mM | 0.281 ml | 1.403 ml | 2.807 ml |
| 5 mM | 0.056 ml | 0.281 ml | 0.561 ml |
Last Update：2024-01-02 23:10:35
(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER - Introduction
Bay-K-8644 ((R)-( )-) is a calcium channel sensitizer with the chemical name (3R)-3-[(2S,3E,5Z,7E)-5-{(2R,3R,5S)-2-[(2S,3R,5S)-5-{(2S,3R,5S)-5-[(1R)-1-hydroxyethyl]-2-(3-methoxyethyl)-7-oxo-2,3,5-triazabicyclo[4.3.0]nona-3,7-diene-4,6-diamine}butanamido}-3-hydroxy-5-(1-hydroxyethyl)-4-oxo-2,3,5-triazabicyclo[4.3.0]nona-3,7-dienylidene]-7-hydroxy-3,6-dioxooct-3-en-2-yl]propanoic acid.
Bay-K-8644 is a non-specific calcium channel sensitizer, mainly used in research and laboratory as an experimental tool. It can increase the activity of L-type calcium channels in the nervous system and cardiovascular system, thereby increasing the influx of calcium ions. In neuroscience research, it is used to enhance the electrical activity of nerve cells and to regulate calcium ion channels released at synapses.
The preparation of Bay-K-8644 is complex and requires a multi-step organic synthesis reaction. The specific preparation method may be more professional, please operate in the laboratory.
Regarding safety information, the toxicity and safety studies of Bay-K-8644 are not sufficient, so strict control of use in the laboratory is required. During use, the laboratory's operating specifications should be observed, appropriate personal protective equipment should be worn, and correct experimental procedures should be followed. If ingestion or contact with skin, eyes, etc., seek medical help immediately.
Bay-K-8644 is a non-specific calcium channel sensitizer, mainly used in research and laboratory as an experimental tool. It can increase the activity of L-type calcium channels in the nervous system and cardiovascular system, thereby increasing the influx of calcium ions. In neuroscience research, it is used to enhance the electrical activity of nerve cells and to regulate calcium ion channels released at synapses.
The preparation of Bay-K-8644 is complex and requires a multi-step organic synthesis reaction. The specific preparation method may be more professional, please operate in the laboratory.
Regarding safety information, the toxicity and safety studies of Bay-K-8644 are not sufficient, so strict control of use in the laboratory is required. During use, the laboratory's operating specifications should be observed, appropriate personal protective equipment should be worn, and correct experimental procedures should be followed. If ingestion or contact with skin, eyes, etc., seek medical help immediately.
Last Update：2024-04-09 20:49:11
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Product Name: Bay-K-8644 ((R)-(+)-) Visit Supplier Webpage Request for quotation
CAS: 98791-67-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 98791-67-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
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